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Where do endocannabinoid receptors reside within the human brain.

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Let’s get into the details. I mean, everything medicinal has directions on how many mgs of this or that you should take and how often. Doesn’t it? People around the world have added cannabidiol to their daily routine as if it were a vitamin or part of their regiment of pills. But, where do you find any sort of direct guidance on how many mgs of CBD you should take and how often? What is the right CBD dosage?

If a person is trying to target a specific condition with cannabidiol, it makes sense for them to search for guidance on how much of it to take. Some conditions are more severe than others and an adult will typically increase their dosage as needed to match the severity of that condition. It’s logical to think that the same sort of concept would apply to CBD, and it should. Most sites I have found, including this one, do not provide a straight answer on how many mgs of cannabidiol you should take at a time. There are a couple of reasons for that.

Why is it Difficult to Find Clear Dosing Instructions for CBD?

How many mgs of CBD should be taken depends often on the condition you are attempting to treat.

First, current research suggests that certain conditions require a large dosage while other conditions can be treated with smaller dosages. That is about as in-depth as it gets, at least so far, in terms of dosing research for the more severe conditions. As seen in a recent Leafly article concerning finding the right CBD doses, someone struggling with multiple sclerosis or Parkinson's disease may require different amounts of cannabidiol if they chose to try it for treatment. There are people that have studied the effects of CBD and probably feel confident they know the right answer, but you will not find official answers. When I say official, I mean answers that have been given the okay from regulatory bodies such as the FDA. That leads to the other reason. Regulations are the second answer as to why finding directions for dosing cannabidiol is so challenging.

Hemp and hemp derived products, such as CBD oil and gummies, just like you can find here on Sugar&Kush, were made legal last year after the 2018 Farm Bill became law. The Farm Bill included The Hemp Farming Act which ended nearly 80 years of prohibition on the hemp plant. Do not confuse hemp with medical or recreational cannabis. That stuff remains federally illegal. Like anything else here in the U.S., or for that matter in any industrialized country, implementing rules and regulations takes time. Federal and state regulatory bodies will not spend time and resources building a structure of regulations and oversight until something is actually legal.

We are waiting on the completion of federal rules and oversight before we officially provide instructions on how much CBD an individual should consider taking and how often. In fact, the FDA held their first public hearing about creating oversight for the CBD industry on May, 31st 2019. Many industry professionals stood before the committee to try and compel the FDA to fast track the implementation of rules. The committee fired back questions as well, some of which could not be answered. The meeting was certainly a step forward, but it also showed that the FDA does not feel comfortable with its understanding of CBD quite yet.

Having explained that, I would be happy to provide more context to help you decide where to start with dosing and the process by which you can discover the most optimal measures of CBD for the condition you are looking to treat. I have written it before and I will again now, it’s better to crawl before you walk or run. It is important to remember that the effects of CBD are subtle. It does not get you high, and it does not have immediate pain killing effects or calm you down instantly. When you first start taking cannabidiol, do not get over anxious for immediate results. It could be upwards of a week before you start noticing that some of those nagging problems have dissipated.

The Bigger Picture

The human endocannabinoid system has been left to its own devices ever since prohibition started 80 years ago. Our body produces endocannabinoids on its own, but the human body has adapted and evolved with the world around it. Our bodies have always had nutrients provided to it from the outside world and depends on that continuing to be true. At one point in time cannabinoids were regularly introduced to our bodies through the food we ate until the federal government decided it was best to prohibit the consumption of cannabinoids from the hemp plant and began eradicating it.

Cannabidiol blocks other molecules from binding to CB1 and CB2 receptors.Since phytocannabinoids (cannabinoids like CBD that are produced by plants) have been reintroduced into our body, we have one more weapon to help us live a little more comfortably in this world. So, now that we have reattained cannabidiol, how do we optimize its use? Remember, it does not fit into the CB1 or CB2 receptors of our ECS. It blocks other molecules from binding to ECS receptors and promotes the internal production of our endocannabinoids. Can we take too much CBD at once and overdose? Nobody has ever died from taking too much of it, at least not on record. Can you still take too much CBD? Yes, but that is true of anything. Again, let’s walk before we run.

You may have heard that CBD sort of cancels out THC. That’s because cannabidiol is preventing tetrahydrocannabinol (THC) from getting to the receptors. But, CBD does bind to other receptors in other systems. In fact, when an individual takes a large dose, maybe 200 mgs of CBD, that individual will start feeling different effects from the CBD as it starts binding with other internal systems besides the ECS. The best example of where large doses of cannabidiol makes sense is people taking it for seizures as an anticonvulsant. People looking to reduce seizures can take hundreds of mgs of CBD per dose.


It becomes a trial and error process. If you are looking to reduce inflammation and the chronic pain that comes from it, you may be fine starting with just 10 mgs of CBD and seeing if that helps. If not, bump up the dosage to 25 mgs of CBD. Sugar and Kush 500mg CBD gummies have 25 mgs in each gummy bear. That is a sort of middle of the road for a dose of cannabidiol. It may be that it takes two gummies, so 50 mgs, in order for it to be effective. If you are looking to treat anxiety issues, it may require an even larger dose. But, there is something else to consider as well when determining how much to take.

Our internal systems change. The number of receptors in a particular system like the ECS can vary over time. At some points there could be a lot of receptors and the next moment there could be a lot less. These receptors are found in the lining of cell membranes. Cells die and are replaced all the time. The amount of receptors will vary between cell generations. How does that impact how much of a CBD dose you are going to take? Well, one week a 25 mg gummy could work great and the following week it could take 50 mgs. Once you get into a rhythm of taking cannabidiol, you will begin to understand and know when to up your dose and test out lowering the dose too.


Once you understand how to dose CBD just for you, then life should start becoming more comfortable.

Sugar&Kush will put out a more detailed guidance on how much CBD to take at a time once they understand how the government wants to see it framed. In the meantime, the benefits of CBD are real and I hope this has helped you to understand how to approach finding the right dose of CBD for you. It may sound complicated, but just give it a try and go through the trial and process. Part of the design of gummy bears and tinctures is that they are small so you can take them with you while you about your busy day and conveniently take more whenever you need to.